Frontal and lateral scans of mouse lungs with fibrosis (grey), before and after treatment with nanoparticles carrying drugs. Image: Guillem Garaulet and Francisca Mulero, CNIO
Nano-carriers for drug release into senescent cells - technology science news

Senescent cells accumulate during aging, and play an active role in aging-related diseases. Scientists have now developed a drug delivery tool that specifically targets senescent cells by employing the high lysosomal (degradative) activity of these cells. Nanoparticles carrying drugs have been designed in such a way that they will go to the lysosomes, and thus release their drugs in senescent cells. In a mouse model of lung fibrosis, these nanoparticles effectively removed senescent cells, and the lung tissue regenerated. For the treatment of a cancer in mice, chemotherapy first induced the formation of senescent cells, which were then destroyed by the drugs brought by the nanoparticles. This combined therapy reduced the tumor. This versatile drug delivery system is expected to become an efficient tool for the treatment of various illnesses.

Read the full story: IRB Barcelona
Scientific publication: EMBO Molecular Medicine