February 19, 2019

    Methyllycaconitine could be useful for treatment of opioid relapse
    A potential novel treatment for drug relapse revealed - short science articles

    Addiction relapse is associated with cues which are scenarios associated with the drug intake like the place of consumption, group of friends etc and treating relapse is extremely important for the overall treatment of the addict. Now, researchers have tested the drug methyllycaconitine (MLA) which is derived from the Delphinium plants which blocked relapse of morphine in mice and rats. This drug is a blocker of the alpha-7-nicotinic receptor of the acetylcholine neurotransmitter. The brain region 'hippocampus' which is usually associated with emotional memories is the site of action of this drug. This is interesting also because the acetylcholine system is usually associated with nicotine addiction and could indicate a common thread for several drug addictions.

    Read the full story: University of Bath
    Scientific publication: Addiction Biology


    A bacterial injection could make our brains resilient to stress
    Could we immunize against stress? - short science articles

    Researchers have found that transferring beneficial bacteria could produce long-lasting anti-inflammatory effects which could make the brain more resilient to stress. Rats were injected with the beneficial bacteria Mycobacterium vaccae for 3 weeks and this resulted in a shift of the brain towards an anti-inflammatory state. Previous research has shown that trauma or illness can sensitize certain brain regions to subsequent stressors thereby leading to mood disorders. Interestingly, Mycobacterium vaccae was able to block this sensitizing effect of stress too. If this could be replicated in humans, then maybe we could develop bacteria based immunizations for certain mood disorders.

    Read the full story: University of Colorado Boulder
    Scientific publication: Brain Behaviour and Immunity


    A new protein discovered could provide insights in depression
    A new type of depression identified - short science articles

    Depression affects 300 million individuals worldwide and while treatments do exist, these are dependent on only one disease model (lack of serotonin and norepinephrine) and those patients who do not fit this model do not benefit from treatment. Now, neuroscientists have discovered that a protein 'RGS8' plays a role in depression. The RGS8 protein controls a hormone receptor MCHR1 which is involved in regulating sleep, feeding and mood. This MCHR1 is inactivated by the RGS8 protein. Mice with higher expression of RGS8 in their nervous system showed lower signs of depressive-like behaviour. Also, there were structural differences in the hippocampus (the brain region involved in memory and mood) in mice with higher expression of the RGS8 protein as compared to mice who had lower expression. This makes RGS8 a promising candidate for depression-like behaviour treatment.

    Read the full story: Hiroshima University
    Scientific publication: Neuroscience


    Hunger could manifest as anger if we interpret our emotions incorrectly
    Hangry = hungry + angry? What makes it so- short science articles

    We all have experienced getting angrier as we become increasingly hungry. But this is dependent on a lot more than just a fall in blood sugar. Researchers have found that hungry people feel greater levels of unpleasant emotions like stress and hate. But, there are two things that contribute towards negative emotions when we get hungry: context and self-awareness. We feel 'hangry' when we feel unpleasant due to hunger but our brain interprets it as negative emotions for other people or situations. Further, people who are more aware of their hunger being manifested as an emotion makes them less likely to become 'hangry'.

    Read the full story: American Psychological Association
    Scientific publication: Emotion


    Non-coding RNAs form regulatory networks in brain cells
    Network of non-coding RNAs identified in the brain - neuroscience news

    RNA is typically known to encode genetic information from the DNA to direct protein synthesis. However, most of the RNA does not code for proteins at all, but are regulatory molecules that modify protein synthesis. A new study has found that different types of such non-coding RNA form a network in the brain, consisting of two microRNAs (very short, as their name indicates), one circular RNA, and one long non-coding RNA. This network ensures that the levels of one microRNA, miR-7 are kept extremely low, and those of one circular RNA, Cdr1as, high. The precise function of the network is still not completely known, but other recent research suggests that it might influence neuronal activity.

    Read the full story: Massachusetts Institute of Technology
    Scientific publication: Cell


    Visiting new places offers the opportunity to learn. This concept was used in mice to study memory formation.
    New memory formation depends on genes related to autism and schizophrenia - neuroscience news

    A new study has found that two proteins act together in the process of memory formation in the hippocampus of mice that were placed in a new environment. One of these proteins is FMRP, which has been associated with the autism-like condition of Fragile X syndrome. FMRP is a protein that binds mRNA and hence regulates the production of peptides and proteins. During memory formation FMRP upregulates the synthesis of a protein known as neurogranin that is typically found in contact points between neurons, the synapses. This protein has been linked to schizophrenia in humans. Thus, this study not only identifies FMRP and neurogranin as important players in memory formation, but also suggests that both are involved in cognitive disabilities observed in autism and schizophrenia.

    Read the full story: Picower Institute – MIT
    Scientific publication: Proceedings of the National Academy of Sciences of the USA


    How does one become aware of what one has seen? This question is coming closer to answer in a new study that used transcranial magnetic stimulation in the prefrontal cortex (the most forefront part of the brain). It turns out that cooperation of two regions in this part of the brain bring confidence of what is being seen. The dorsolateral prefrontal cortex collects the visual input, and when the input is strong enough, it sends it to the anterior prefrontal cortex. The anterior prefrontal cortex takes the evidence from the dorsolateral part and assigns confidence, or awareness, of what is being seen. This process is an example of metacognition, or the understanding of one's own thought processes.

    Read the full story: Georgia Institute of Technology
    Scientific publication: Journal of Neuroscience


    An angry boss reflects on his behaviour and engages in repairing his attitude
    Your Boss: Angry today, nice tomorrow? - short science articles

    Researchers used previous research which studied the impact of abusive bosses on the employees and focused to see how the bosses themselves responded to their own extreme behaviour. Not only did the bosses felt guilty of their own abusive behaviour but also they felt that they lost 'moral credit'. Further, working in a place where moral and ethical values are extremely important makes the supervisors more attentive to their behaviour and they experience guilt when they act abusively. These supervisors are then prone to engage in cleansing behaviours following their abusive acts. This shows that supervisors too engage actively in repairing their behaviours due to the insight they develop.

    Read the full story: Michigan State University
    Scientific publication: Applied Psychology


    Parietal cortex of the brain could be the seat of spiritual experiences
    Where does the brain process spiritual experiences - short science articles

    Spiritual experiences need not be only religious in nature, but also could be other feelings like a feeling of oneness with nature. Some spiritual experiences are profound and have deep impacts on a persons' life. Now, scientists have recognized the brain region associated with such experiences. The parietal cortex, a brain region which is usually associated with awareness of self and attentional processing seems to be the place of origin of such experiences. Researchers interviewed 27 adults to identify previous stressful and relaxing life episodes and found similar parietal cortex brain activity as subjects imagined past spiritual experiences even though the experiences were quite different. This could help us identify how spiritual experiences impact mental health.

    Read the full story: Yale University
    Scientific publication: Cerebral Cortex


    Food for thought: hunger is signaled in the brain through the cerebrospinal fluid
    New route for delivering messages in the brain - neuroscience news

    While communication from neuron to neuron through synapses and via the endocrine system are well known routes to spread news in the brain, researchers have found that there is still a third manner by which the brain sends messages. This manner is through the liquid in the brain, the cerebrospinal fluid, which was originally thought to be only important for waste management. Now it turns out this liquid can carry messenger molecules such as the neuropeptide MCH that signals hunger and reduces energy expenditure. This sort of signaling is very different as the synaptic “point-to-point” neuronal communication, as the message is able to reach essentially all parts of the brain, in this case to initiate eating.

    Read the full story: University of Southern California
    Scientific publication: Cell Metabolism


    Brain regions associated with thinking have more real estate in bigger brains. Photo credit: P.K. Reardon, NIMH Developmental Neurogenomics Unit
    Thinking areas account for more space allocation in bigger human brains - short science articles

    Some human brains are bigger than others and researchers have found out that this additional area is attributed to the thinking areas of the brain at the expense of relatively slower growth in the motor, emotional and sensory areas by studying the brain scan data of more than 3000 people. Further, these high expanding regions of the brain have increased connectivity between neurons and also consumed higher energy with increased gene expression associated with energy metabolism. This could give us insights into how certain mental disorders alter the brain size related to genetic information and impact of environmental influence.

    Read the full story: National Institute of Health
    Scientific publication: Science


    brain ageing slowed due to increased social interactions
    Slower brain ageing and memory preservation linked to higher social ties - short science articles

    Researchers have found that mice that are grouped together have better memories and healthier brains compared to mice which live in pairs. Grouped mice performed better on experiments that tested identification of objects moved to a new place and also developed better escape strategies in maze based memory tasks. Further pair housed mice had higher signs of inflammation in the brain tissue as compared to group-housed mice indicating that the later had better cognitive health. This research supports the notion that social connections indeed help in preserving the brain health.

    Read the full story: Ohio State University
    Scientific publication: Frontiers in Aging Neuroscience


    Depression is not linked to having an abortion
    Having an abortion is not associated with depression- short science articles

    Several studies claim that abortion causes psychological harm to women and this narrative shapes state policies restricting access to abortion facilities in the US. Hence researchers studied the relationship between abortion and mental health by analyzing the data of 400,000 Danish women between 1980 - 1994. They studied the risk of antidepressant use as a proxy for depression around the time of an abortion. Interestingly, the researchers found that the risk of antidepressant use doesn't change one year before to one year after an abortion with their use declining as the time after an abortion increased. While women who had an abortion had a higher risk of antidepressant use, this risk was the same both the year before and after an abortion which indicates that this higher risk could be due to some other preexisting mental condition and not associated with abortion.

    Read the full story: University of Maryland
    Scientific publication: JAMA Psychiatry


    Distinct neurons in the brain identify different types of taste
    No more sweet tooth - short science articles

    Researchers have found that the innate desire for sweet taste and distaste for bitter taste can be deleted from the brain by manipulating certain neurons in the amygdala which is the emotional center of the brain. The amygdala is divided into distinct regions for bitter and sweet taste just as that seen previously in the taste identifying region of the brain. This distinction gives an opportunity to independently manipulate the neurons. When neurons for sweet taste in the amygdala were switched off the animals responded to water just as to sugar. By manipulating the neurons the researchers could change the perceived quality of taste and turned sweet taste to aversive taste or a bitter taste to an attractive one. This could give insights in eating disorders.

    Read the full story: Columbia University
    Scientific publication: Nature


    Early life seizures could lead to modifications of brain networks
    Brain networks associated with autism switch on due to early life seizures -short science articles

    There are silent neuron connections in the brain which gradually become activated with experience in children. However early life seizures lead to 'unsilencing' of these connections which could remove them from the reservoir necessary for the development of cognitive and language skills thereby increasing the likelihood of developing autism. In the study conducted in mice, researchers found that inducing seizures in a particular brain region changes the receptors in the neurons leading to disruption of proper development of that brain region. Treating these mice with NBQX an anticonvulsant drug prevented this premature unsilencing of these brain circuits and hence also avoided the behavioural abnormalities observed. So, the time period of treatment post early life seizures is critical for avoiding development of neurological disorders.

    Read the full story: Penn Medicine
    Scientific publication: Cell Reports


    The placenta could play a central role in schizophrenia
    Missing link in Schizophrenia: the placenta - short science articles

    There has been a long debate of the nature vs nurture role on the development of schizophrenia. Now, researchers have found an explanation connecting the early life complications, genetic risk and their influence on mental illness and it all happens to converge on the placenta. While previous studies have always concentrated on how genes associated with behavioural disorders directly affect brain development before birth, researchers have found that several genes which are associated with risk of schizophrenia alter early brain development indirectly by influencing the health of placenta. Moreover, the more these genes were activated in the placenta the more the placenta showed signs of inflammation indicating a central role of the placenta in development of schizophrenia.

    Read the full story: LIEBER INSTITUTE FOR BRAIN DEVELOPMENT
    Scientific publication: Nature Medicine


    African-Americans have higher risk of depression
    Higher risk of depression in African-Americans and Latinos compared to Whites - short science articles

    Researchers collected data from 12,272 participants over a period of 7 years from 2005-2012 in the age range of 40-70 years and found that Latinos and African-Americans were more likely to have higher levels of chronic stress and unhealthy behaviour like cigarette smoking, drinking, insufficient exercise and poor diet compared to whites. This is opposite to previous understanding that engaging in unhealthy behaviour reduces effects of chronic stress on depression in African-Americans. Further, opposite to previous research, the study found that all in groups chronic stress was associated with less binge drinking behaviour.

    Read the full story: National Institute of Health
    Scientific publication: Preventive Medicine


    Childhood stressful situation could increase aggression in adulthood
    Living in high-risk situations increases the likelihood of kids becoming violent adults - short science articles

    Researchers have for the first time provided scientific evidence pointing out that children who experience abuse, migration, cannabis or alcohol use and live in big cities in their childhood have a higher tendency of becoming violent aggressive adults. These children have at least 10 times higher chances of aggressive behaviour of being convicted of sexual assault, battery, murder or manslaughter in their adulthood. A further epigenetic analysis of a subset of individuals showed that they had higher levels of histone deacetylase 1 (HDAC1) which indicates an environmental influence on the genes.

    Read the full story: Springer
    Scientific publication: Molecular Psychiatry


    Early signs of Alzheimer's disease do not necessarily mean that a person will develop the disease
    Most persons with preclinical Alzheimer’s disease will not develop dementia during their lifetimes - neuroscience news

    Hopeful news about Alzheimer’s disease: most persons with early signs of the disease will not develop dementia during their lifetimes. These early signs are known as biomarkers, and present themselves before physical symptoms of the disease manifest themselves. However, biomarkers do not show the likelihood for a person that tests positive will develop Alzheimer’s disease. Risk is related to age, lifetime and the status of the disease during the screening. Thus, biomarkers should be looked at in conjuntion with lifetime risk factors.

    Read the full story: University of California – Los Angeles
    Scientific publication: Alzheimer’s and Dementia – The Journal of the Alzheimer’s Assocation


    A new drug could help protect harmful effects of space radiation
    A way to protect our brain from radiation if we travel to Mars - short science articles

    While NASA and SpaceX are planning to send humans to Mars in our lifetime, one hurdle is to figure out how would we protect our 'space travellers' from the harmful effects of cosmic radiation in deep space. To this end, researchers found that exposure of simulated space radiation to mice resulted in problems associated with memory, social interactions, anxiety, all of which are linked to the activation of the microglia cells which are a part of the brain immune system. However, if these mice were treated with the drug PLX5622 developed by pharmaceutical company Plexxikon Inc, they showed a reversal of several symptoms. This is hypothesized to be due to replacing damaged microglia with normal healthy ones providing first evidence of effectiveness of the drug.

     Read the full story: University of California San Francisco
    Scientific publication: Scientific Reports


    When bored at work, people tend to use the internet more for personal or recreational reasons
    Use of internet for recreation during work is a response to boredom - science news in brief

    A new study suggests that personal use of internet during working hours (known as cyberloafing) is due to boredom. Many people are bored at work for various reasons, and cyberloafing could be a coping behavior that helps them relax. The research involved 463 non-instructional university personnel and concluded that those with a relatively low workload were more likely to say they felt bored at their job. This in turn was associated with greater use of internet recreationally at work. There is no consensus currently on whether cyberloafing is a negative behavior or not.

    Read the full story: Psypost
    Scientific publication: Computers in Human Behavior


    Regrowing brain tissue in mice with blood vessels in purple and nerve fibres in green. Image: UCLA
    New gel helps to regrow the brain after stroke - neuroscience news

    Researchers have succeeded at regrowing brain scar tissue after a stroke in mice, using a newly developed gel. This biomaterial suppresses scarring, and creates new scaffolding for neurons and blood vessels. This is a remarkable finding, as the brain has only limited capacity to renew itself after injury, and rather absorbs dead tissue. Scientists hope that the gel may one day be used in humans that have suffered from stroke.

    Read the full story: University of California – Los Angeles
    Scientific publication: Nature Materials


    Lower neuron connections associated with higher intelligence
    If you are smarter, then your brain has fewer connections - short science articles

    Neuroscientists used neuroimaging techniques to look for insights into the wiring of the brain microstructure especially in relation to their intelligence. Participants were brain scanned to quantify the dendrites which are extensions of the neurons which helps them communicate with other neurons. These participants also completed an IQ test and scientists found that higher the intelligence of a person, lower is the number of connections. Usually, larger brains are associated with more neuronal connections and hence considered to have more computation power. However, since the brains of intelligent people show fewer connections, this could mean that intelligent brains are in fact lean and show higher efficient due to lower connections.

    Read the full story: Ruhr-Universität Bochum
    Scientific publication: Nature Communications


    Gene to avoid protein misfolding and deposition identified
    Gene to prevent brain disease identified - short science articles

    Abnormal protein deposits are seen in neurological disorders like Alzheimer's and Parkinson's disease. One of the reasons for these deposits could be a failure of the cells to transmit proper genetic information to proteins. Now researchers have identified the gene Ankrd16, which prevents the protein from aggregating. Usually, transfer of information from the cell to the protein is controlled carefully, it is biologically proofread and corrected to avoid production of improper proteins. Low level of Ankrd16 gene allows the formation of improperly constructed proteins and increasing its expression rescues Purkinje cells (a type of neurons) which usually die if proofreading fails.

    Read the full story: University of California San Diego
    Scientific publication: Nature


    Protein dispositions are a hallmark of Alzheimer's disease
    Gene discovered that prevents brain disease - neuroscience news

    Scientists have found a gene that filters out proteins that are incorrectly folded, especially those proteins with a substitution of an amino acid (building blocks of proteins) by a particular amino acid called serine. Low expression of this gene, Ankrd16, puts neurons at risk of dying, as the proofreading ability in these neurons is not as efficient in the absence of Ankrd16. Incorrect folding of proteins leads to protein dispositions in the brain and causes Alzheimer’s disease. The newly discovered gene might thus help to better understand why protein dispositions form, which is still a mystery to date.

    Read the full story: University of California – San Diego
    Scientific publication: Nature


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