Tbx3 (green) plays a crucial role for the function and maintenance of satiety neurons in the brain. Image: modified from Quarta, C. & Fisette, A. et al. (Nature Metabolism)
The yin and yang of obesity - brain short science news

The feelings of hunger and satiety are controlled in the brain, in the hypothalamus to be precise. Here two cell types with opposing function mediate the balance between eating and fasting.

Now, scientists have discovered that the transcription factor Tbx3 plays a key role in metabolism. When Tbx3 is absent or modified, the cells that give the feeling of satiety cannot make the proper cellular messengers that signal to stop eating.

Scientists hope that Tbx3 might become a target for drug therapy to restore energy and sugar metabolism in obese individuals.

Read the full story: Helmholtz Zentrum
Scientific publication: Nature Metabolism