Negative mood linked to neuropsychiatric disorders is localized in the brain's caudate nucleus
Pinpointing pessimism - neuroscience news

By stimulating a brain region known as the caudate nucleus, scientists found that experimental animals generate rather negative expectations. Such negative mood makes the stimulated animals focus on negative outcomes of a given situation, more than on potential benefits. By giving more weight to negative outlook, the animals make more negative decisions. The localization of negative moods to the caudate nucleus is relevant for patients with neuropsychiatric disorders such as anxiety or depression, who manifest similar negative outlooks that cloud decision-making.

Read the full story: Massachusetts Institute of Technology
Scientific publication: Neuron