Alzheimers disease. Image from
Mitochondria could be the seat of Alzheimer disease

Mitochondria, the cell organelles which are concerned with energy production might show the first signs of Alzheimer's pathology. Researchers at the Arizona State University found that oligomeric beta-amyloid (OA-beta) accumulates in the mitochondria and disrupts its normal functioning. Neurons from deceased Alzheimer patients showed a drastic reduction of protein synthesized by mitochondrial genes pointing towards their degradation by OA-beta. However, the most exciting finding was that one could protect these neurons from OA-beta if they were pretreated CoQ10 which assists in reducing oxidative stress thereby opening a potential line of treatment.

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