Obesity is linked to a ACBP protein synthesized by astrocytes in the hypothalamus
Key brain protein involved in food intake discovered - interesting science news

This might come as a shock; however researchers have revealed that controlling your weight might be dependent on a brain protein regardless of the amount of exercise or diet you could be doing. The protein in question is acyl-CoA-binding protein (ACBP).

ACBP is produced by astrocytes, which are cells which usually support the neurons. Researchers have shown that the proopiomelanocortin neurons which reduce our food intake are in close communication with the astrocytes that produce ACBP in a specific brain region called the arcuate nucleus of the hypothalamus.

This brain region is the feeding center of the brain and controls both food intake and energy expenditure. Absence of the ACBP gene in astrocytes in this brain region promotes obesity which indicates that it is involved in weight control.

Read the full story: University of Montreal Hospital Research Centre (CRCHUM)
Scientific publication: Journal of Clinical Investigation

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