Modulating epigenetic mechanisms for treatment. Image by
Getting silenced genes to express again

Prader-Willi syndrome is a genetic disorder which affects 1 in 15,000 births and is the most common cause of fatal childhood obesity. Unlike other genetic diseases, children with Prader-Willi syndrome have all genes intact but the gene inherited from the mother is silenced. The protein produced by gene ZNF274 is suspected to be involved in this process. However, researchers Maéva Langouët and colleagues at the University of Connecticut were able to induce expression of this gene by deleting the gene for ZNF274. This could branch out a novel therapy for children with this condition.

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