New insights in Parkinson's pathology:
Getting rid of old astrocytes may help avoid Parkinson disease development

Parkinson patients display higher astrocyte senescence in their post-mortem tissue. A mouse model resembling this sporadic development of Parkinson's by exposure to the neurotoxin paraquat was shown to have these senescent astrocytes too. However, clearing up these senescent astrocytes and other inflammatory cells prevented the development of signs of Parkinson's disease in mice, providing the first evidence of its kind in live mammals. This is an exciting development providing a novel avenue for treatment of this condition which affects approximately 10 million people in the world.

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