Alzheimer's disease might not be caused by plaques in the brain, but by a blood-clotting factor
Blood-clotting factor responsible for Alzheimer’s disease - brain short science news

The blood-clotting protein fibrinogen could be at the basis of cognitive decline, such as seen in Alzheimer’s disease, a new study reports.

It was already known that Alzheimer’s patients have abnormalities in the blood vessel network in the brain, and now it turns out that fibrinogen from the blood is responsible for a series of molecular and cellular events that destroy the connections between neurons. It does so by activating the brain’s immune system and triggers them to attack synapses which mediate the contact between neurons.

These observations could change the way we think about cognitive decline in Alzheimer’s disease, and how to cure it.

Read the full story: Gladstone Institutes
Scientific publication: Neuron


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