Second HIV postive patient treated with stem cell potentially cured
Prolonged HIV remission in a second patient achieved - interesting science news

After the ‘Berlin patient’ 10 years ago, another patient treated with stem cells from donors who have genetic mutation that prevents expression of an HIV receptor CCR5 has shown sustained HIV remission even after stopping treatment. This patient is named as the ‘London patient’.

The patient was first diagnosed with HIV in 2003 and has been on anti-retroviral therapy since 2012. However, he developed Hodgkin's Lymphoma and hence received a haematopoietic stem cell transplant from a donor with two copies of the CCR5Δ32 allele in 2016.

The CCR5 receptor is important for the HIV to enter the host cells and mutation in these receptors prevents it from doing so thereby preventing the infection of host cells. Knocking out the CCR5 receptor in patients with HIV could be one way to use gene therapy in treating HIV.

Read the full story: University College of London
Scientific publication: Nature


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