In neonatal diabetes half of the produced insulin is mutated which induces a state of chronic stress in the pancreas
Possible mechanism for neonatal diabetes discovered

Some babies are diagnosed with diabetes within the first six months of life. In many cases, this is linked to mutations in one copy of the genes coding for insulin. Since half of the produced insulin is still normal, it is not clear how the diabetes forms in infants.

Now, a new study suggests that the mutant insulin produced by the affected gene induces a chronic stress that disturbs the growth and development of insulin-producing cells from the pancreas. This triggers diabetes itself.

The study used stem cells from people carrying insulin gene mutations to reach the conclusion. Using the CRISPR techniques the researchers were able to reverse the damage. The findings may help devise new ways to prevent neonatal diabetes.

Read the full story: AlphaGalileo
Scientific publication: eLife