Mouth bacteria associated with chronic gum disease seem to play a role in Alzheimer's disease pathology
Is Alzheimer’s disease caused by mouth bacteria? - health short science news

A very surprising culprit of Alzheimer’s disease has been identified: Porphyromonas gingivalis (Pg), the bacterium commonly associated with chronic gum disease.

Scientists have found this bacterium in the brain of patients with Alzheimer’s disease. In mice, Pg could infect the brain and increased the production of amyloid beta, a component of the plaques commonly found in the brain of Alzheimer’s patients. Finally, scientists could block neurotoxicity caused by the bacteria, leading to a milder infection of the brain and cessation of abnormal amyloid beta production and neuroinflammation in the hippocampus of mice.

Although promising, the results still need further support from additional experiments to causally link mouth bacteria with Alzheimer’s disease, the scientists say.

Read the full story: University of Louisville
Scientific publication: Science Advances


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