A computer-based approach can predict which proteins could be expressed on the surface of a cell
For the first time, scientists can describe proteins on the cell surface - latest science news

A wide array of proteins is located on the surface of a cell. Each cell has a different repertoire of proteins on its surface (the surfaceome) and knowing exactly which proteins are where could greatly help to treat diseases.

Now, using a machine learning approach, scientists were able to predict which proteins are expressed on the cell surface with an accuracy of 93%. In addition, the researchers were able to show that the number of surface proteins varies widely by cell type.

“In developing new drugs, it’s crucial to know about functional units with multiple proteins and bear them in mind as potential targets,” said Professor Bernd Wollscheid, the lead author.

Read the full story: ETH Zurich
Scientific publication: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Scientific publication: Current Opinion in Chemical Biology