Cancer cell's adaptations to hypoxia pave the way for safe treatment strategies
Exploiting hypoxia to treat cancers - cancer news

Targeting cancers without damaging healthy tissue is the ideal scenario to treat tumors. Now, scientists are on their way to master this challenge after identifying a cancer cell receptor that is switched on during conditions of hypoxia. Hypoxia often occurs in cancers, as they are developing quicker than their oxygen supply would permit. Cancer cells therefore have to use other strategies to ensure their growth, and the identified receptor might play a role in this. Indeed, when stopping the switching on of the receptor, known as GPRC5A, when oxygen levels are low triggered cancer cell death. The experiments were done in a dish, but scientist aim to explore this further to develop a safe treatment of cancers in the future.

Read the full story: University of Bristol
Scientific publication: EMBO Molecular Medicine