Soon, blood urea measurements might predict which cancer patients will benefit from immunotherapy
Disrupted nitrogen metabolism plays a role in cancer - health science news

Nitrogen is a building block of proteins, RNA and DNA, and is therefore in high demand by cancer cells. Scientists have now found that disrupted nitrogen metabolism in the liver reduces the concentration of a nitrogenous waste product, urea, in certain cancers, and increases the availability of nitrogen for cancer cells. This makes the cancer cells on the one hand more aggressive, but on the other hand also more vulnerable to immunotherapy, in patients and experimental animals. It should now become possible to design a blood test to monitor urea levels in cancer patients, and predict in which of these patients immunotherapy will likely have beneficial effects, i.e. in those patients with low blood urea.

Read the full story: Weizmann Institute
Scientific publication: Cell