Steroid treatment can trigger metabolic changes such as a fatty liver (shown here) via the transcription factor E47 Image: Helmholtz Zentrum München
Cortisone treatments cause metabolic side effects through transcription factor E47 - health short science news

Treatment of patients with cortisone can cause metabolic side effects, a new study shows.

Cortisones are prescribed as antiinflammatory drugs to treat for example asthma or rheumatism for decades. They are also used for the treatment of cancer, and autoimmune diseases.

Now, it appears that corticosterone induces metabolic effects, especially in the liver, through the upregulation of the transcription factor E47, which changes the gene expression pattern in the cells. This leads to elevated blood sugar (so-called steroid diabetes) and fat levels, or a fatty liver. While these results were obtained in laboratory animals, further study needs to confirm similar effects of cortisone treatment in humans.

Read the full story: Helmholtz Zentrum München
Scientific publication: Nature Communications