Biochemical dysfunctions leading to complications in diabetes have been identified
Complications of diabetes better understood - health short science news

A new study has shown that glucose metabolism in endothelial cells lining the blood vessels is increased in high concentrations of glucose, like those seen in diabetes. This was caused by the slower degradation of a glucose-metabolizing enzyme (HK2) in these cells.

Prolonged activity of HK2 leads to increased formation of a glucose-derived substance called methylglyoxal (MG) which damages blood cells, the kidneys, the retina and nerves in arms and legs.

Importantly, the study describes that a novel dietary supplement called glyoxalase 1 inducer (Glo 1 inducer) could correct the dysfunctional glucose metabolism in endothelial cells in cell cultures, suggesting that Glo 1 inducer could be considered for future treatment of complications caused by diabetes.

Read the full story: University of Warwick
Scientific publication: Scientific Reports