Squamous cell skin cancer tumors with lactate production (a byproduct of glucose consumption) in purple. The tumor with lactate production blocked (left) grew at the same rate as the tumor with normal lactate production (right). Image: UCLA Broad Stem Cell Research Center/Nature Communications
Cancer dogma overthrown: cancer cells do not require increased glucose - health short science news

Cancer cells can grow and develop without increased glucose consumption. These surprising finding from studies on squamous cell skin cancer challenge the long-hold believe, documented in thousands scientific reports, that cancer cells need large amounts of glucose to fuel their excessive growth and cell division rate.

In the current study, researchers blocked the conversion of glucose into lactate in rat cancers to strongly reduce glucose uptake by cancer cells. It turned out that cancers developed just as fast as those in rats with normal glucose metabolism.

Apparently, at least skin cancer cells can switch to other molecules as energy source. This explains why therapies based on cancer cell metabolism have been in majority unsuccessful to date in clinical trials.

Read the full story: UCLA
Scientific publication: Nature Communications