New treatment option of pancreatic cancer is possibly on the horizon. Image: Scienific Animations Inc under Creative Commons License 4.0
Breaking the defense wall of pancreatic cancer - cancer short science news

Weakening the defensive wall around a tumor so that chemomedicines can reach cancer cells better: if that approach proves to be effective in humans, that would offer prospects for pancreatic cancer, the form of cancer with the worst chance of survival.

The wall consists of cells that stretch and contract and produce thick layers of proteins, creating a fibrous network in which the blood vessels that run to the tumor are squeezed and close. As a result, chemomedication does not end up properly in the cancer cells.

Researchers have now found a protein, AV3, that can affect the cells that form the wall. As a result, the wall weakens and blood vessels open. The combination of AV3 and chemotherapy reduces tumors in human pancreatic tissue that had been implanted in mice. While this is hopeful, more clinical research is necessary to translate these results to an effective treatment option of patients.

Read the full story: University of Twente
Scientific publication: Science Advances