Bacteria are absent in the spleen of a normal rat (left), but occur in the spleen of MAVS-deficient rat (right). Spleen cells in blue, bacteria in red. Image: Ana Hennino, David Bauché, Emilie Plantamura / CIRI
What a virus detection system, microbiota and skin allergies have to do with each other - health science news

Biologists have observed that mice lacking the MAVS gene, necessary for virus detection by the immune system, have an altered composition of intestinal bacteria and severe allergic skin reactions. Transfer of the abnormal bacteria (microbiota) to normal mice caused the same skin allergies as in MAVS-deficient mice, showing that gut microbiota are responsible for the skin health problems. Furthermore, the altered gut microbiotica increased the permeability of the intestines, so that some bacteria could enter the body and migrate to the spleen and lymph nodes. This increased the skin allergies even further. Thus, there is a direct link between the immune system, gut microbiota, and skin allergies, which could be taken into consideration for development of new therapies.

Read the full story: CNRS
Scientific publication: Proceedings of the National Academy of Sciences of the USA