James P. Allison (left) and Tasuku Honjo (right) discovered how to unleash the immune system to fight tumors. Credit: NobelPrize.org
The 2018 Nobel Prize in Physiology or Medicine awarded for cancer therapy - daily science news in short

This year, the Nobel Prize in Physiology or Medicine goes to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation”. The two scientists discovered how inhibiting the brakes of the immune system can be used to fight cancer. James P. Allison studied a known protein that slows down the immune system. He realized the potential of releasing the brake and thereby unleashing our immune cells to attack tumors. In parallel, Tasuku Honjo discovered a protein on immune cells and revealed that it also operates as a brake, but with a different mechanism of action. Both discoveries were later used for new cancer therapies.

Read the full story: ScienceBriefss
Scientific publication: The Nobel Committee for Physiology or Medicine