While tumors tend to increase their genetic variability as a consequence of uncontrolled DNA replication and cell division, the immune system fights back and restricts such genetic variability. Researchers came to this conclusion following experiments with multicolor barcoding of a mouse lymphoma cell line. When these cells were given to male and female mice, some clones became dominant, especially in females, while others disappeared due to the action of T cells. T cells are immune cells that are activated in immunotherapy, which may thus lead to natural selection of certain cancer cell clones to dominate, or induce more genetic homogeneity of a tumor. These observations may thus be important for the treatment of cancers. In the video you can see how T cells (purple) attack and destroy cancer cells (grey).

Read the full story: Institut Pasteur
Scientific publication: Science Immunology